Alzheimer’s / Dementia Treatment in India
Alzheimer is the severe version of dementia named after the neurologist Dr. Alois Alzheimer. It is a kind of progressive neurodegenerative disorder associated with the gradual loss of cognitive functions such as thinking, memory, reasoning and behavioral skills. The Alzheimer disease initially affects its victim subtly with the preliminary symptoms being disorientation and memory loss, but in later stages the disease can progress to an extent of complete dependency on others for the basic activities of daily living. Research suggests that a host of factors beyond genetics and age, are responsible for the onset and development of this disorder.
Like all other forms of dementia, Alzheimer is also caused due to severe nerve damage, mainly due to the formation of proteinaceous plaques and tangles. There are two distinct hallmarks of Alzheimer’s mainly deposition of tangles inside the brain cells and amyloid proteins clogging the spaces between the neurons, these formation hampers smooth passage of signals from motor neurons ultimately resulting in their death or degeneration. The root cause of these formations is still to be identified, but scientists are relating some epigenetic changes to be associated with them.
The strong progressive neurodegeneration has identified to be mainly responsible factor for the observed memory failure, personality changes and difficulty coping with the day to day activity.
Conventionally only supportive treatments were present to temporarily relieve the pain or the symptoms, additionally there are many support services available for the effective management of some activities and programs such as day care services or nursing programs. Although the damage in terms of death of neurons cannot be halted or reversed with this treatment approach till the discovery of stem cells.
Symptoms of Alzheimer
Major Manifestations of Alzheimer’s, in patients include the following:
Difficulty performing familiar tasks
Disorientation to time and places
Poor or decreased judgement
Problems with the abstract thinking
Changes in mood or behavior
Changes in personality
Loss of initiative
Stem cells are the master cells of the body, mainly differentiating into the required type of cells upon administering a proper cocktail of growth factors and stimulatory agents in vitro. The stem cell therapy approach mainly focuses on delivering the sufficient number of Adult Autologous Stem Cells which will travel into multiple areas of the brain where the damage has occurred.These transplanted stem cells are potential to transform into new brain cells which are needed for the replacement of damaged cells. They also help in creating a microenvironment that will secret some of the enzymes required for making connections to replace lost parts of the complex network.